The Requirements for Ontologies in Medical Data Integration: A Case Study

Evidence-based medicine is critically dependent on three sources of information: a medical knowledge base, the patients medical record and knowledge of available resources, including where appropriate, clinical protocols. Patient data is often scattered in a variety of databases and may, in a distributed model, be held across several disparate repositories. Consequently addressing the needs of an evidence-based medicine community presents issues of biomedical data integration, clinical interpretation and knowledge management. This paper outlines how the Health-e-Child project has approached the challenge of requirements specification for (bio-) medical data integration, from the level of cellular data, through disease to that of patient and population. The approach is illuminated through the requirements elicitation and analysis of Juvenile Idiopathic Arthritis (JIA), one of three diseases being studied in the EC-funded Health-e-Child project.Comment: 6 pages, 1 figure. Presented at the 11th International Database Engineering & Applications Symposium (Ideas2007). Banff, Canada September 200

Cloud provider capacity augmentation through automated resource bartering

© 2017 Elsevier B.V. Growing interest in Cloud Computing places a heavy workload on cloud providers which is becoming increasingly difficult for them to manage with their primary data centre infrastructures. Resource scarcity can make providers vulnerable to significant reputational damage and it often forces customers to select services from the larger, more established companies, sometimes at a higher price. Funding limitations, however, commonly prevent emerging and even established providers from making a continual investment in hardware speculatively assuming a certain level of growth in demand. As an alternative, they may opt to use the current inter-cloud resource sharing systems which mainly rely on monetary payments and thus put pressure on already stretched cash flows. To address such issues, a new multi-agent based Cloud Resource Bartering System (CRBS) is implemented in this work that fosters the management and bartering of pooled resources without requiring costly financial transactions between IAAS cloud providers. Agents in CRBS collaborate to facilitate bartering among providers which not only strengthens their trading relationships but also enables them to handle surges in demand with their primary setup. Unlike existing systems, CRBS assigns resources by considering resource urgency which comparatively improves customers’ satisfaction and the resource utilization rate by more than 50%. The evaluation results verify that our system assists providers to timely acquire the additional resources and to maintain sustainable service delivery. We conclude that the existence of such a system is economically beneficial for cloud providers and enables them to adapt to fluctuating workloads

Cloud Market Maker: An automated dynamic pricing marketplace for cloud users

© 2015 Elsevier B.V. Abstract Cloud providers commonly incur heavy upfront set up costs which remain almost constant whether they serve a single or many customers. In order to generate a return on this investment, a suitable pricing strategy is required by providers. Established industries such as the airlines employ dynamic pricing to maximize their revenues. In order to increase their resource utilization rates, cloud providers could also use dynamic pricing for their services. At present however most providers use static schemes for pricing their resources. This work presents a new dynamic pricing mechanism for cloud providers. Furthermore, at present no platform exists that provides a dynamic unified view of the different cloud offerings in real-time. Due to a rapidly changing landscape and a limited knowledge of the cloud marketplace, consumers can often end up choosing a cloud provider that is more expensive or does not give them what they really need. This is because some providers spend significantly on advertising their services online. In order to assist cloud customers in the selection of a suitable resource and cloud providers in implementing dynamic pricing, this work describes an automated dynamic pricing marketplace and a decision support system for cloud users. We present a multi-agent multi-auction based system through which such services are delivered. An evaluation has been carried out to determine how effectively the Cloud Market Maker selects the resource, dynamically adjusts the price for the cloud users and the suitability of dynamic pricing for the cloud environment

Providing traceability for neuroimaging analyses

IntroductionWith the increasingly digital nature of biomedical data and as the complexity of analyses in medical research increases, the need for accurate information capture, traceability and accessibility has become crucial to medical researchers in the pursuance of their research goals. Grid- or Cloud-based technologies, often based on so-called Service Oriented Architectures (SOA), are increasingly being seen as viable solutions for managing distributed data and algorithms in the bio-medical domain. For neuroscientific analyses, especially those centred on complex image analysis, traceability of processes and datasets is essential but up to now this has not been captured in a manner that facilitates collaborative study. Purpose and MethodFew examples exist, of deployed medical systems based on Grids that provide the traceability of research data needed to facilitate complex analyses and none have been evaluated in practice. Over the past decade, we have been working with mammographers, paediatricians and neuroscientists in three generations of projects to provide the data management and provenance services now required for 21st century medical research. This paper outlines the finding of a requirements study and a resulting system architecture for the production of services to support neuroscientific studies of biomarkers for Alzheimer’s Disease.ResultsThe paper proposes a software infrastructure and services that provide the foundation for such support. It introduces the use of the CRISTAL software to provide provenance management as one of a number of services delivered on a SOA, deployed to manage neuroimaging projects that have been studying biomarkers for Alzheimer’s disease. ConclusionsIn the neuGRID and N4U projects a Provenance Service has been delivered that captures and reconstructs the workflow information needed to facilitate researchers in conducting neuroimaging analyses. The software enables neuroscientists to track the evolution of workflows and datasets. It also tracks the outcomes of various analyses and provides provenance traceability throughout the lifecycle of their studies. As the Provenance Service has been designed to be generic it can be applied across the medical domain as a reusable tool for supporting medical researchers thus providing communities of researchers for the first time with the necessary tools to conduct widely distributed collaborative programmes of medical analysis

A generic model for real-time scheduling based on dynamic heterogeneous data

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